FOOD SCIENCE ›› 2011, Vol. 32 ›› Issue (5 ): 331-335.doi: 10.7506/spkx1002-6630-201105072

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Research Progress in Regulation of Fatty Acid Secretion in Engineered E. coli Strain

MENG Xin1,CHENG Tao1,2,LI Liang-zhi1,YANG Jian-ming1,LIU Wei1,XU Xin1,XIAN Mo1,*   

  1. 1. Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China;
    2. School of Materials and Chemical Engineering, Jiangxi University of Science and Technology, Ganzhou 341000, China
  • Received:2010-05-27 Revised:2011-02-01 Online:2011-03-15 Published:2011-03-03
  • Contact: XIAN Mo E-mail:xianmo@qibebt.ac.cn

Abstract: Fatty acids produced by oil-producing microorganisms are stored in cells as the form of triglyceride. The extraction of these fatty acids from the cells is involved in complex processing, high production cost and serious environmental pollution. Targeted regulation for the production of free fatty acids by engineered E. coli strains is becoming one of the hottest topics in current research, which will be an effective strategy for reducing energy crisis and providing high-quality and low-cost raw materials of oil. The research progress of some genes (tesA, fadD and fadL) and regulatory protein (MsbA) related to extracellular secretion of fatty acids in E. coli has been reviewed in this paper. Meanwhile, the target regulation of fatty acid metabolism by using molecular biology and metabolic engineering strategies has been proposed, with the aim of provideing a new direction for producing extracellular fatty acids.

Key words: fatty acid, metabolic regulation, transportation

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